- George Felix Allen (1952– ), from Albemarle County, 2001–2007, Republican.
- William Segar Archer (1789–1855), from Amelia County, 1841–1847, Whig.
- James Barbour (1775–1842), from Orange County, 1815–1825.
- John Strode Barbour Jr. (1820–1892), from Alexandria, 1889–1892, Democrat.
- Lemuel Jackson Bowden (1815–1864), from Williamsburg, 1863–1864, Republican.
- Richard Brent (d. 1814), from Prince William County, 1809–1814, Democratic-Republican.
- Thomas Granville Burch (1869–1951), from Martinsville, 1946, Democrat.
- Harry Flood Byrd (1887–1966), from Winchester, 1933–1965, Democrat.
- Harry Flood Byrd Jr. (1914– ), from Winchester, 1965–1971, Democrat; 1971–1983, Independent.
- John Snyder Carlile (1817–1878), from Harrison County (now West Virginia), 1861–1865, Unionist.
- John Warwick Daniel (1842–1910), from Lynchburg, 1887–1910, Democrat.
- John Wayles Eppes (1773–1823), from Buckingham County, 1817–1819, Democratic- Republican.
- William Branch Giles (1762–1830), from Amelia County, 1804–1815, Democratic-Republican.
- Carter Glass (1858–1946), from Lynchburg, 1920–1946, Democrat.
- William Grayson (1740–1790), from Prince William County, 1789–1790.
- Robert Mercer Taliaferro Hunter (1809–1887), from Essex County, 1847–1861, Democrat.
- Eppa Hunton (1822–1908), from Fauquier County, 1892–1895, Democrat.
- John Warfield Johnston (1818–1889), from Washington County, 1870–1883, Democrat.
- Timothy Michael Kaine (1958– ), from Richmond, 2013– , Democrat.
- Richard Henry Lee (1732–1794), from Westmoreland County, 1789–1792.
- Benjamin Watkins Leigh (1781–1849), from Richmond, 1834–1836, Whig.
- John Francis Lewis (1818–1895), from Rockingham County, 1870–1875, Republican.
- William Mahone (1826–1895), from Petersburg, 1881–1887, Readjuster.
- Thomas Staples Martin (1847–1919), from Albemarle County, 1895–1919, Democrat.
- Armistead Thomson Mason (1787–1819), from Louisa County, 1816–1817, Democratic-Republican.
- James Murray Mason (1798–1871), from Winchester, 1847–1861, Democrat.
- Stevens Thomson Mason (1760–1803), from Loudoun County, 1794–1803, Democratic-Republican.
- James Monroe (1758–1831), from Albemarle County, 1790–1794.
- Andrew Moore (1752–1821), from Rockbridge County, 1804–1809, Democratic-Republican.
- Wilson Cary Nicholas (1761–1820), from Albemarle County, 1799–1804, Democratic- Republican.
- Richard Elliott Parker (1783–1840), from Clarke County, 1836–1837, Democrat.
- Isaac Samuels Pennybacker (1805–1847), from Harrisonburg, 1845–1847, Democrat.
- James Pleasants (1769–1836), from Goochland County, 1819–1822, Democratic-Republican.
- John Randolph (1773–1833), from Charlotte County, 1825–1827.
- Harrison Holt Riddleberger (1844–1890), from Shenandoah County, 1883–1889, Readjuster.
- William Cabell Rives (1793–1868), from Albemarle County, 1832–1834, 1836; 1837–1839, Democrat; 1841–1845, Whig.
- William Henry Roane (1787–1845), from Hanover County, 1837–1841, Democrat.
- Charles Spittal Robb (1939– ), from Fairfax County, 1989–2001, Democrat.
- Absalom Willis Robertson (1887–1971), from Lexington, 1946–1966, Democrat.
- William Lloyd Scott (1915–1997), from Fairfax, 1973–1979, Republican.
- William Belser Spong Jr. (1920–1997), from Portsmouth, 1966–1973, Democrat.
- Claude Augustus Swanson (1862–1939), from Pittsylvania County, 1910–1933, Democrat.
- John Taylor (1753–1824), from Caroline County, 1792–1794, 1803, 1822–1824.
- Henry Tazewell (1753–1799), from Williamsburg, 1794–1799, Democratic-Republican.
- Littleton Waller Tazewell (1774–1860), from Norfolk, 1824–1832.
- Paul Seward Trible Jr. (1946– ), from Newport News, 1983–1989, Republican.
- John Tyler (1790–1862), from Charles City County, 1827–1836.
- Abraham Bedford Venable (1758–1811), from Prince Edward County, 1803–1804, Democratic-Republican.
- John Walker (1744–1809), from Albemarle County, 1790.
- John William Warner (1927– ), from Fauquier County, 1979–2009, Republican.
- Mark Robert Warner (1954– ), from Alexandria, 2009– , Democrat.
- James Henry Webb Jr. (1946– ), from Fairfax County, 2007–2013, Democrat.
- Waitman Thomas Willey (1811–1900), from Monongalia County (now West Virginia), 1861–1863, Unionist.
- Robert Enoch Withers (1821–1907), from Lynchburg, 1875–1881, Democrat.
Members of the United States Senate from Virginia
Members of the United States Senate representing Virginia are listed here in alphabetical order. Each entry includes life dates if known, a member’s area of residence when first elected, period of service, and party affiliation when known. Before 1795 and again from the 1810s into the 1830s there were no well-organized political parties or parties were in flux, and for those time periods no affiliation is listed. Between 1795 and the 1810s most members are identified as Federalists or as Democratic-Republicans.