Paquiquineo leaves Cádiz, Spain, for New Spain (present-day Mexico), before going to the Chesapeake Bay.

Paquiquineo and another, unnamed Virginia Indian sail from Cádiz, Spain, their ship part of a fleet captained by Pedro Menéndez de Avilés. They are bound for New Spain (present-day Mexico), where they will make a brief stop before Paquiquineo joins a Dominican mission to the Chesapeake Bay.